Lysyl Oxidase-like Protein from Bovine Aorta
نویسندگان
چکیده
منابع مشابه
LOXL2 (lysyl oxidase-like 2)
The LOXL2 gene is located on chromosome 8p21.2p21.3 (Jourdan-Le Saux et al., 1998). It is composed of fourteen exons and thirteen introns, distributed through approximately 107 kb of genomic DNA (Fong et al., 2007). Two transcripts of sizes 3.6 kb and 4.9 kb have been reported, with the smaller transcript much more abundant and resulting from three possible termination sites located 690 bp, 740...
متن کاملLOXL3 (lysyl oxidase-like 3)
Note LOXL3 is part of the lysyl oxidase (LOX) family, the members of which are secreted extracellular matrix enzymes. LOXL3 contains a C-terminal region that is conserved in all five isoforms of this copper-dependent amine oxidase family. The domains included within this region are a copper-binding site, lysyl and tyrosine residues that form the lysyltyrosine-quinone cofactor (LTQ) and a cytoki...
متن کاملReaction pathway of bovine aortic lysyl oxidase.
The catalysis of amine oxidation by lysyl oxidase has been probed to assess for the likely order of substrate binding and product release and to discriminate between mechanistic alternatives previously proposed for other copper-dependent amine oxidases using molecular oxygen as a substrate. Lineweaver-Burk plots revealed a pattern of parallel lines when the oxidation of n-butylamine was followe...
متن کاملInhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer
Lysyl oxidase (LOX) and LOX-like (LOXL) enzymes are key players in extracellular matrix deposition and maturation. LOX promote tumour progression and metastasis, but it may also have tumour-inhibitory effects. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue. In...
متن کاملExpression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4.
The lysyl oxidase-like protein 4 (LOXL4) is the latest member of the emerging family of lysyl oxidases, several of which were shown to function as copper-dependent amine oxidases catalyzing lysine-derived cross-links in extracellular matrix proteins. LOXL4 contains four scavenger receptor cysteine-rich domains in addition to the characteristic domains of the LOX family, including the copper-bin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m109499200